What question did this study set out to answer?

This research aims to explore how the length of time to delivery affects fetal exposure to sevoflurane during cesarean sections under general anesthesia.

April 1, 2026International Journal of Obstetric Anesthesia0 citationsOpen Access

Time-dependent placental transfer of sevoflurane during cesarean delivery under general anesthesia

Q: What does this research mean for the field?

The induction-to-delivery interval is strongly associated with fetal sevoflurane exposure, whereas maternal end-tidal sevoflurane concentration does not predict fetal blood levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

JHJennifer Herzog-NiescerySt. Josef-Hospital NBNikolaj Matthias BotteckKatholisches Klinikum Bochum PKPeter KernRuhr University Bochum

Key Points

This research aims to explore how the length of time to delivery affects fetal exposure to sevoflurane during cesarean sections under general anesthesia.
Analyzed the induction-to-delivery interval during cesarean deliveries
Measured fetal sevoflurane blood levels
Evaluated the relationship between delivery time and fetal exposure
Longer times to delivery are associated with increased fetal sevoflurane exposure.
End tidal sevoflurane concentration does not accurately predict fetal blood levels.

Abstract

Highlights Induction-to-delivery interval is strongly associated with fetal sevoflurane exposure. Longer time to delivery increases transfer of sevoflurane to the fetus End tidal sevoflurane concentration does not predict fetal blood levels.

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