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April 1, 2026ChemistrySelect

In‐Vitro and In‐Silico Insights on Ganodermadiol as Potential Therapeutic for Type 2 Diabetes Mellitus: A Study on Biological Inhibitors From  Ganoderma Lucidum

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Authors

MAMuhammad AfzalUniversity of Central PunjabENEsha NaveedUniversity of Central PunjabNMNoshaba MehmoodUniversity of Central Punjab

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Overview

Evaluates Ganodermadiol's antidiabetic potential using biological inhibitors from Ganoderma lucidum, suggesting a promising therapeutic approach.

Key Points

  • The study aims to isolate and identify biological inhibitors from Ganoderma lucidum and assess their potential in managing Type 2 diabetes mellitus.
  • Isolated and purified biological inhibitors from Ganoderma lucidum using column chromatography.
  • Analyzed fractions for phytochemical constituents and functional groups with Fourier Transform Infrared Spectroscopy.
  • Identified bioactive metabolites through Liquid Chromatography-Mass Spectrometry (LC-MS).
  • Conducted enzyme inhibition assays to evaluate antidiabetic activity.
  • Performed in silico molecular docking analysis to assess binding affinity to the PPARG receptor.
  • The highest α-glucosidase inhibition observed was 95% at 6 mg/ml in fraction O.
  • The highest α-amylase inhibition achieved was 90% at 6 mg/ml in fraction O.
  • Molecular docking showed Ganodermadiol had a strong binding affinity of -8.1 kcal/mol toward the PPARG receptor.
  • Fractions of varying polarity revealed diverse bioactive compounds with varying biological potentials.

Cite This Study

Afzal et al. (2026) studied this question.

synapsesocial.com/papers/69ccb7b016edfba7beb89bdahttps://doi.org/10.1002/slct.202504356
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