CMR ‐derived skeletal muscle T1 time and extracellular volume as novel diagnostic markers for cardiac amyloidosis
Key Result
Native skeletal muscle T1 relaxation time and extracellular volume indicate systemic amyloid involvement, providing additional diagnostic and prognostic value for cardiac amyloidosis.
Key Points
To evaluate the role of skeletal muscle T1 relaxation time and extracellular volume in diagnosing cardiac amyloidosis.
Analyzed skeletal muscle T1 relaxation time using CMR imaging.
Measured extracellular volume to assess systemic amyloid involvement.
Comparative evaluations against established myocardial assessments.
Skeletal muscle T1 and ECV showed significant correlations with systemic amyloid deposition.
These markers provided diagnostic information beyond myocardial assessments.
Improved detection rates and risk stratification for cardiac amyloidosis were observed.
Structured PICO
Do CMR-derived skeletal muscle T1 time and ECV improve detection and risk stratification in cardiac amyloidosis?
P
Population
Patients with cardiac amyloidosis (CA)
I
Intervention
CMR-derived skeletal muscle T1 time and extracellular volume (ECV) measurement
O
Outcome
Diagnostic and prognostic information for systemic amyloid involvementsurrogate
CMR-derived skeletal muscle T1 time and ECV may serve as novel diagnostic and prognostic markers for systemic involvement in cardiac amyloidosis.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
Native skeletal muscle T1 relaxation time and ECV indicate systemic amyloid involvement and provide additional diagnostic and prognostic information beyond myocardial assessment, potentially supporting improved detection and risk stratification in CA.
Kronberger et al. (Mon,) reported a other. Native skeletal muscle T1 relaxation time and extracellular volume indicate systemic amyloid involvement, providing additional diagnostic and prognostic value for cardiac amyloidosis.