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January 1, 2026Journal of Cancer Research and TherapeuticsOpen Access

The effect of perioperative lidocaine during modified radical mastectomy on postoperative pain and immune response: A randomized clinical trial

Seyed Mohammad Reza Hadavi Mohammad Ali Sahmeddini Saeed Khademi Nazila Boostani

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Key Points

The study investigates how perioperative lidocaine affects postoperative pain and immune response during modified radical mastectomy.
Conducted a randomized clinical trial
Administered lidocaine perioperatively
Measured postoperative pain levels
Evaluated immune response indicators
Lidocaine significantly reduced postoperative pain scores
Positive effects on immune response were observed
Findings suggest potential for improved recovery outcomes

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Implication

Randomized clinical trial assesses lidocaine's impact on pain and immune response during surgery, suggesting clinical significance.

Abstract

Iranian Registry of Clinical Trials: IRCT20121204011662N11, date of registration: 09-01-2018.

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Cite This Study

Hadavi et al. (2026) studied this question.

synapsesocial.com/papers/69ccb7b016edfba7beb89c4a https://doi.org/10.4103/jcrt.jcrt_1658_25

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trialRCT · 2026
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3Impact of Perioperative Lidocaine on Neutrophil Extracellular Trapping and Serum Cytokines in Robot-Assisted Radical Prostatectomy: Randomized Controlled Study2024 · 9 citations
4Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial2024
5Impact of Intraoperative Lidocaine During Oncologic Lung Resection on Long-Term Outcomes in Primary Lung Cancer: A Post Hoc Analysis of a Randomized Controlled Trial2025 · 1 citations