Assessment of miRNAs as transcriptional regulators in respiratory syncytial virus infection through computational analysis and molecular docking studies

Fig 1. RSV genome organization and proteins with length.

Fig 2. Target sites/nucleotides positions of miRNAs in the genome of RSV predicted by miRanda algorithm. The ggplot has been depicted between nucleotides on x-axis and energy values on y-axis. The list of different genes has been listed with different colors.

Fig 3. Target sites/nucleotides positions of miRNAs in the genome of RSV predicted by RNAHybrid server. The ggplot has been depicted between nucleotides on x-axis and energy values on y-axis. The list of different genes has been listed with different colors. The gray dots labeled as NA indicate nonapplicable cases.

Fig 4. A Venn diagram of predicted miRNAs by RNAHybrid and miRanda tools. Twelve miRNAs were jointly predicted by both computational tools.

Fig 5. Predicted structures of miRNAs.

Fig 6. Docking scores of predicted miRNAs using HNA docking server.

Fig 7. Docking complexes of predicted miRNAs with mRNA.

Fig 8. Docking complexes miR-200c and miR204 interaction, the green and grey colors represent miRs whereas, dark orange color represents mRNA nucleotides.

Fig 9. Docking complexes miR-502c and miR2278 interaction, the purple and light blue colors represent miRs whereas, dark orange color represents mRNA nucleotides.

Fig 10. Docking complexes miR-3135 and miR4327 interaction, the red and dark blue colors represent miRs whereas, dark orange color represents mRNA nucleotides. The H-bonds represented by red dotted lines and the nucleotide involved in interactions are highlighted by dotted purple rectangles.

Fig 11. Docking complexes miR-4633 and miR-4761.

Fig 12. Docking complexes miR-6081 and miR6732 interaction, the cyan and purple colors represent miRs whereas, dark orange color represents mRNA nucleotides. The H-bonds represented by red dotted lines and the nucleotide involved in interactions are highlighted by dotted purple rectangles.