Does pregnancy increase the risk of SCAD recurrence in women with prior spontaneous coronary artery dissection?
Pregnancy after SCAD appears to be well-tolerated without a clear increased risk of SCAD recurrence, though data is limited by small sample sizes and selection bias.
This study found that most women tolerated pregnancy and lactation after SCAD without evidence for increased risk of SCAD recurrence when compared with women with a history of SCAD who did not experience pregnancy. Although this study is reassuring and indicates complex contributors to SCAD recurrence, the results need to be interpreted prudently because of study selection bias and the small total number of women who became pregnant after SCAD. The notable hemodynamic changes that occur with pregnancy and severe presentation of pregnancy-associated SCAD are reasons for concern when considering pregnancy after SCAD.
Tweet et al. (Wed,) studied this question.