Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition

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Abstract

JAK2 inhibition by Rux in MCAO mice decreased STAT3 phosphorylation, thus inhibiting the expression of downstream proinflammatory cytokines and the acetylation of histones H3 and H4 on the NLRP3 promoter, resulting in the downregulation of NLRP3 inflammasome expression.

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Zhu et al. (Thu,) studied this question.

synapsesocial.com/papers/69cd0448e0d6becfeecf4349 https://doi.org/https://doi.org/10.3389/fimmu.2021.714943

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