Experimental work demonstrates the functionalization of Isoflurane to create CF2-based ethers, suggesting novel uses in medicinal chemistry.
Defluorination of polyfluorinated aliphatic substances (PFAS) is highly essential due to increasing concerns over PFAS-related environmental issues. In the present study, we demonstrate that commercially available Isoflurane (belongs to PFAS family) can be repurposed as a valuable fluorinated feedstock through selective C(sp3)–F bond functionalization. A simple, transition-metal-free protocol converts Isoflurane into a reactive fluoroalkene intermediate that undergoes nucleophilic addition with complex phenols. This strategy provides access to diverse, valuable CF2-based ethers bearing an additional chloro handle. The method also enables the preparation of deuterated analogues, expanding the toolkit of fluorinated and deuterated motifs for medicinal chemistry.
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Kumawat et al. (2026) studied this question.
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