Anti-inflammatory mechanism of female and male Smilax china root extracts via analysis of MAPK and NF-κB/COX-2/PGE ₂ signaling pathways in RAW 264.7 Cells

MiYoung Lee; So-Hyeon Bok; Taeho Ahn; Chun-Sik Bae

doi:10.7853/kjvs.2026.49.1.83

March 30, 2026Korean Journal of Veterinary ServiceOpen Access

Anti-inflammatory mechanism of female and male Smilax china root extracts via analysis of MAPK and NF-κB/COX-2/PGE ₂ signaling pathways in RAW 264.7 Cells

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Key Points

To investigate the anti-inflammatory mechanisms of Smilax china root extracts in male and female samples through specific molecular pathways.
Analyzed root extracts from male and female Smilax china.
Evaluated effects on RAW 264.7 immune cells.
Investigated MAPK and NF-κB/COX-2/PGE2 signaling pathways.
Demonstrated a significant reduction in inflammatory markers.
Showed differential effects between male and female root extracts.
Indicated modulation of MAPK and NF-κB pathways.

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Implication

Experimental analysis of Smilax china root extracts shows anti-inflammatory effects via MAPK and NF-κB signaling pathways in immune cells, suggesting therapeutic potential.

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Lee et al. (2026) studied this question.

synapsesocial.com/papers/69cd79915652765b073a6822 https://doi.org/10.7853/kjvs.2026.49.1.83

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Anti-inflammatory mechanism of female and male Smilax china root extracts via analysis of MAPK and NF-κB/COX-2/PGE ₂ signaling pathways in RAW 264.7 Cells

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

Anti-inflammatory mechanism of female and male Smilax china root extracts via analysis of MAPK and NF-κB/COX-2/PGE ₂ signaling pathways in RAW 264.7 Cells

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

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