“Target species complex” concept: Strengthening environmental risk assessment of engineered gene drives

Key Points

• The aim is to improve environmental risk assessment methodologies for engineered gene drives targeting malaria vectors.
• Developed a conceptual framework for assessing ecological risks.
• Analyzed existing risk assessment methodologies.
• Proposed criteria for evaluating target species interactions.
• Identified key factors affecting ecological outcomes of engineered gene drives.
• Demonstrated the need for a comprehensive assessment framework.
• Highlighted gaps in current environmental risk assessments for genetic interventions.