What question did this study set out to answer?

To assess the effectiveness of metronidazole compared to vancomycin for treating moderate Clostridioides difficile infections.

April 1, 2026Open Access

Metronidazole versus Vancomycin for a Moderate Clostridioides difficile Infection Defined by the Japanese Severity Score (MN Criteria): A Propensity Score-Matched Cohort Study

Key Points

To assess the effectiveness of metronidazole compared to vancomycin for treating moderate Clostridioides difficile infections.
Conducted a single-center retrospective cohort study from 2011 to 2025.
Identified adult inpatients with moderate CDI receiving either oral metronidazole or vancomycin.
Employed propensity score matching to balance participant characteristics.
Comparative effectiveness of metronidazole and vancomycin was evaluated based on patient outcomes.
No specific numerical results were provided, but trends in effectiveness between the two treatments were observed.

Abstract

Objective To compare the effectiveness of initial metronidazole (MNZ) and vancomycin (VCM) for moderate Clostridioides difficile infection (CDI), as defined by the Japanese MN criteria. Methods: A single-center retrospective cohort study (2011-2025). Adult inpatients with an initial episode of moderate CDI who received oral MNZ or VCM were identified. Propensity score matching (1:1; caliper 0.2) balanced the demographics, severity indicators, comorbidities, and concomitant medications.

Bookmark

View Full Paper

Bookmark

View Full Paper

Metronidazole versus Vancomycin for a Moderate Clostridioides difficile Infection Defined by the Japanese Severity Score (MN Criteria): A Propensity Score-Matched Cohort Study

Key Points

Abstract

Cite This Study