Mechanically Induced Dentin Mineralization and DMP1 Upregulation Following Orthodontic Tooth Movement

TAKEUCHI Satoka; Ogasawara Takeshi; Uezono Masayoshi; AOKI Kazuhiro; MORIYAMA Keiji

doi:10.5357/koubyou.93.1_31

March 30, 2026THE JOURNAL OF THE STOMATOLOGICAL SOCIETY JAPANOpen Access

Mechanically Induced Dentin Mineralization and DMP1 Upregulation Following Orthodontic Tooth Movement

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Key Points

This research aims to explore how orthodontic tooth movement affects dentin mineralization and related molecular changes.
Used a rat model for the study
Applied continuous mechanical forces to simulate orthodontic tooth movement
Analyzed dentin mineralization and molecular responses, particularly DMP1 levels
Dentin mineralization increased following application of mechanical forces
DMP1 expression levels were significantly upregulated in response to orthodontic treatment

Implication

Investigation reveals OTM influences dentin mineralization in rats, suggesting significant biological effects.

Abstract

Introduction : Dentin undergoes progressive mineralization by external stimuli. Orthodontic tooth movement (OTM) applies continuous mechanical forces to teeth, yet its biological effects on dentin mineralization remain unclear. We aimed to investigate the influence of OTM on dentin mineralization and the associated molecular responses using a rat model.

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Cite This Study

Satoka et al. (2026) studied this question.

synapsesocial.com/papers/69cd79bb5652765b073a6a0a https://doi.org/10.5357/koubyou.93.1_31

View Full Paper

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Mechanically Induced Dentin Mineralization and DMP1 Upregulation Following Orthodontic Tooth Movement

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanically Induced Dentin Mineralization and DMP1 Upregulation Following Orthodontic Tooth Movement

Key Points

Implication

Abstract

Discussion

Cite This Study

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