What question did this study set out to answer?

This research aims to compare the effects on serum cytokines and chemokines from JAK inhibition and IL-6 inhibition in iMCD patients.

April 1, 2026Drug Discoveries & TherapeuticsOpen Access

Effects of Janus kinase inhibition and interleukin 6 inhibition on serum cytokine/chemokine in idiopathic multicentric Castleman disease

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Authors

SFShoichi FukuiNagasaki University Hospital RSRemi SumiyoshiNagasaki University Hospital TKT. KogaNagasaki University

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Implication

Comparative longitudinal study assesses cytokine responses in iMCD patients treated with two therapies, suggesting similar effects but differing mechanisms.

Key Points

This research aims to compare the effects on serum cytokines and chemokines from JAK inhibition and IL-6 inhibition in iMCD patients.
Longitudinal study design evaluating 41 serum cytokines/chemokines in 10 patients with plasma-cell-type iMCD.
Five patients received filgotinib (JAK1 preferential inhibitor) for 52 weeks, while five received tocilizumab for a median of 28 months.
Cytokine levels were compared to those of healthy controls, using Z-scores for normalization.
Both treatment groups showed significant changes in multiple cytokines, with 12 cytokines significantly altered in each group.
Three cytokines (IL-6, IL-15, PDGF-AA) had differing responses between treatments.
Cytokine suppression levels were comparable between filgotinib and tocilizumab (median ΔZ-score: -0.32 vs. -0.27, p = 0.74).

Cite This Study

Fukui et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a095652765b073a6d98 https://doi.org/10.5582/ddt.2026.01000

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Implication

Comparative longitudinal study assesses cytokine responses in iMCD patients treated with two therapies, suggesting similar effects but differing mechanisms.

Effects of Janus kinase inhibition and interleukin 6 inhibition on serum cytokine/chemokine in idiopathic multicentric Castleman disease

Discussion

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Implication

Key Points

Cite This Study

Effects of Janus kinase inhibition and interleukin 6 inhibition on serum cytokine/chemokine in idiopathic multicentric Castleman disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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