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This systematic study explores GBCA stability with zinc and heparin, indicating implications for safety and design.
In their Research Article (DOI: 10.1002/cmdc.202501096) using MRI relaxometry, Patrick Werner and Leif Schröder monitor the transmetallation and transchelation of gadolinium-based MRI contrast agents (GBCAs) in the presence of zinc ions and the glycosaminoglycan heparin. The competition between GBCAs and heparin for Gd ions is revealed by significant changes in relaxation rates. The study highlights stability patterns of linear versus macrocyclic agents and establishes a versatile platform that can illuminate another aspect of GBCA safety and guide the design of more stable agents.
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Werner et al. (2026) studied this question.
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