Transition-metal-free skeletal editing of five- and six-membered N-heterocycles

Liling Pan; Yong HUANG; Xiaoqiang Sun; Ke Yang

doi:10.1039/d6cc00668j

January 1, 2026Chemical Communications

Transition-metal-free skeletal editing of five- and six-membered N-heterocycles

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Key Points

The aim is to explore transition-metal-free methods for skeletal editing of n-heterocycles.
Investigated various n-heterocycles in organic synthesis
Applied transition-metal-free conditions
Analyzed the structural modifications
Successfully edited the skeletal structures of five- and six-membered n-heterocycles
Demonstrated improved efficiency compared to metal-catalyzed methods
Showed potential applications in drug development and material science

Implication

Research demonstrates skeletal editing of n-heterocycles, suggesting novel applications in pharmaceuticals.

Abstract

N-Heterocycles represent ubiquitous structural motifs in pharmaceuticals, natural products, and functional materials. Recently, skeletal editing of these N-heterocycles has garnered considerable attention in organic and medicinal chemistry, owing to its...

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Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a095652765b073a6e75 https://doi.org/10.1039/d6cc00668j

View Full Paper

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Transition-metal-free skeletal editing of five- and six-membered N-heterocycles

Key Points

Implication

Abstract

Discussion

Cite This Study

Transition-metal-free skeletal editing of five- and six-membered N-heterocycles

Key Points

Implication

Abstract

Discussion

Cite This Study

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