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April 1, 2026The Journal of Cell Biology

A regional regulatory axis shapes enteroendocrine cell morphology and function

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Authors

HYHaimeng YuYZYongchao ZhangJSJingyuan Shi

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Overview

Demonstrates how transcription factors shape enteroendocrine cell forms in the gut, indicating distinct gut functions.

Key Points

  • To uncover the regulatory mechanisms influencing the morphology and function of enteroendocrine cells in the Drosophila midgut.
  • Utilized Drosophila as a model organism to study EE morphology
  • Identified the role of Ptx1 in determining EE types
  • Analyzed effects of ectopic expression of transcription factors on EE formation
  • Open-type enteroendocrine cells are predominant in most regions of the gut
  • Closed-type EEs are specific to the middle gastric region
  • Ectopic expression of Ptx1 or esg induces closed-type morphology with impaired amino acid sensing

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a3e5652765b073a7307https://doi.org/10.1083/jcb.202506084
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