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April 1, 2026Neurosurgery

Impact of Postoperative Diffuse-Weighted Imaging Rim Restriction on Neurological Outcomes After Resection of Newly Diagnosed Isocitrate Dehydrogenase-Wildtype Glioblastoma

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Authors

GMGrazia MennaUniversità Cattolica del Sacro CuoreNANadeem Al-AdliUniversity of North Carolina at Chapel HillJGJasper K W GerritsenUniversity of California, San Francisco

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Implication

Retrospective analysis investigates neurological outcomes related to DWI rim restriction in glioblastoma, suggesting implications for recovery.

Key Points

  • This study investigates the influence of postoperative diffusion-weighted imaging (DWI) abnormalities on neurological outcomes in glioblastoma patients.
  • Retrospective cohort analysis of 303 glioblastoma patients at UCSF (2017-2021)
  • DWI abnormalities categorized by severity from Grade 0 (no restriction) to Grade 4 (bulky restriction)
  • Measured DWI volumes and diameters of restriction
  • Multivariable regression models assessed associations with neurological deficits.
  • 11 patients (3.6%) had no rim restriction, 81.5% had minimal to moderate restriction, and 14.9% had bulky restriction
  • All DWI abnormalities resolved within 6 months post-surgery
  • Only 3 out of 17 patients with new or worsening deficits had bulky DWI restriction
  • DWI volume and maximum diameter were linked to postoperative deficits, but DWI grade and apparent diffusion coefficient were not.

Cite This Study

Menna et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a615652765b073a778bhttps://doi.org/10.1227/neu.0000000000004012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1200 DWI and ADC Changes in Patients With Glioblastoma IDH-Wild Type Following Surgical Tumor Resection2024 · 1 citations
  2. 2Utility of Early Postoperative DWI to Assess the Extent of Resection of Adult-Type World Health Organization Grade 2 and 3 Diffuse Gliomas2024 · 1 citations
  3. 3The Impact of Postoperative Ischemic Changes on Survival Outcomes in IDH-wildtype Glioblastoma2025
  4. 4Mapping DWI signal reversal and long-term tissue outcomes following endovascular therapy in acute ischemic stroke2025 · 4 citations
  5. 5Diffusion Anisotropy Predicts Directional Progression After Complete Resection of Frontal Glioblastoma2026