Innovative microcolumn chromatography improves mass sensitivity and versatility in liquid and gas applications, suggesting unification of techniques.
Miniaturization of the separation column produces numerous merits in high-performance liquid chromatography (HPLC). The attractive features of micro-HPLC are demonstrated by various applications, in which laboratorymade instruments are employed. Microcolumn-based detection showed versatility and better mass sensitivity of micro-HPLC. The micro-HPLC system is applicable to gas chromatography and supercritical fluid chromatography, leading to unification of chromatography.
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Ishii et al. (1989) studied this question.
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