What question did this study set out to answer?

To review the mechanisms by which exercise and lipoprotein lipase (LPL) activation modulate lipid metabolism and mitigate metabolic disorders such as dyslipidemia, obesity, and diabetes.

April 1, 2026Open Access

Lipid metabolism in relation to exercise and lipoprotein lipase activity

Q: What is the clinical evidence from this study?

Study design: Review. Population: Metabolic diseases (dyslipidemia, obesity, diabetes mellitus, atherosclerosis). Intervention: Exercise and lipoprotein lipase (LPL) activators.

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Key result

Exercise prevents and improves metabolic diseases by activating skeletal muscle lipoprotein lipase activity.

Design

Review

Authors

MKMasataka KusunokiNagoya University Hospital DSDaisuke Sato KTKazuhiko TSUTSUMI

Discussion

Member takes

Implication

Supports exercise counseling for metabolic disease; extends LPL activation as therapeutic target.

Key Points

To review the mechanisms by which exercise and lipoprotein lipase (LPL) activation modulate lipid metabolism and mitigate metabolic disorders such as dyslipidemia, obesity, and diabetes.
Synthesized molecular, animal model, and human clinical evidence examining the effects of exercise training and synthetic LPL activators on lipid metabolism.
Evaluated physiological mechanisms involving skeletal muscle LPL activity, triglyceride hydrolysis into free fatty acids, and mitochondrial uncoupling protein expression.
Exercise training increases skeletal muscle LPL activity, promoting the hydrolysis of VLDL triglycerides into free fatty acids for cellular energy and increasing antiatherogenic HDL-C levels.
Synthetic LPL activation with NO-1886 or human LPL overexpression suppressed visceral and subcutaneous fat accumulation, decreased adipocyte size, and improved insulin resistance.
Endurance exercise programs and LPL activation increased skeletal muscle UCP3 mRNA and protein expression, promoting fat burning and suppressing aortic and coronary atherosclerosis.

Structured PICO

Intervention

Exercise and LPL-activating compounds (e.g., NO-1886)

Exercise prevents and improves metabolic diseases such as diabetes mellitus, atherosclerosis, and obesity by activating skeletal muscle lipoprotein lipase (LPL) activity.

Cite This Study

Kusunoki et al. (2022) conducted a review in Metabolic diseases (dyslipidemia, obesity, diabetes mellitus, atherosclerosis). Exercise and lipoprotein lipase (LPL) activators was evaluated. Exercise prevents and improves metabolic diseases such as diabetes mellitus, atherosclerosis, and obesity by activating skeletal muscle lipoprotein lipase activity.

synapsesocial.com/papers/69cd7ae65652765b073a87c7 https://doi.org/10.18999/njhpfs.45.1.1

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Lipid metabolism in relation to exercise and lipoprotein lipase activity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Lipid metabolism in relation to exercise and lipoprotein lipase activity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider