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April 1, 2026Open Access

Immunohistochemical Localization of Copper-Zinc and Manganese Superoxide Dismutases in Human Tissues

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Authors

AMAfreen MunimKAKei AsayamaFukuoka Institute of TechnologyNUNorihiko UchidaObayashi (Japan)

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Implication

This article examines superoxide dismutases in human tissues, highlighting differences from rat studies.

Key Points

  • The study aims to localize copper-zinc and manganese superoxide dismutases in human tissues using immunohistochemical methods.
  • Conducted immunolocalization of SOD using histochemical staining.
  • Applied indirect immunoenzyme method with rabbit anti-human SOD antisera.
  • Optimized dilution set at 1:10,000 for both CuZnSOD and MnSOD.
  • Compared staining results with previous findings in rat tissues.
  • Intense staining for MnSOD was observed in human pancreatic exocrine cells, renal tubular cells, and cardiac myocytes.
  • CuZnSOD showed high reactivity in human gastrointestinal and bronchial epithelium but was absent in cardiac myocytes and pancreatic islets.
  • Differences were noted between human and rat tissue staining profiles, especially in epithelial linings.

Cite This Study

Munim et al. (1990) studied this question.

synapsesocial.com/papers/69cd7af55652765b073a8838https://doi.org/10.34429/00003169
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification and characterization of copper zinc superoxide dismutase of the patients reperfused after myocardial infarction2018
  2. 2A simple method for clinical assay of superoxide dismutase.1988 · 4,535 citations
  3. 3Superoxide dismutase: tissue, cellular, and subcellular distribution in adult canine heart1985 · 28 citations
  4. 4Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury1998 · 258 citations
  5. 5Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice2009 · 57 citations