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This research aims to understand how corticosterones affect the structure and function of isolated subcellular membranes.

April 1, 2026Open Access

Studies on Structure and Function of the Biological Membrane Systems : III. The Modes of Action of Corticosterones on The Isolated Subcellular Membranes

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This research aims to understand how corticosterones affect the structure and function of isolated subcellular membranes.
Examined the effects of hydrocortisone and 11-desoxycorticosterone on isolated subcellular compartments.
Used electron microscopy and biochemical analysis to assess structural and enzymatic changes.
Concentrations applied were higher than physiological levels, primarily at 10^-4-10^-3 M.
11-DOC caused respiratory inhibition and uncoupling of oxidative phosphorylation in mitochondria.
Led to configurational changes and swelling in mitochondrial inner membranes.
Produced fragmentation of lysosomal membranes and enzyme release.
Induced dislocation of lipids and formation of electron-dense bodies on membranes.

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The study investigates corticosterone effects on subcellular membranes, highlighting implications for membrane structure and function.

Yoshiaki Itatsu (1972) studied this question.

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