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Ventilatory response to hypercapnia is influenced by genetics in young monozygotic and dizygotic twins, suggesting hereditary factors play a role.
The present study was made to examine the importance of heredity of the ventilatory response to hypercapnia. The subjects were 17 monozygotic twin (MZ) pairs and 4 dizygoitic twin (DZ) pairs, aged from 11 to 22 years. The ventilatory response to CO2 was determined by the CO2 rebreathing method for each subject. In this study, correlation (r=0.82, p<0.01) was found between hypercapnic ventilatory response (ΔVE/ΔPACO2) for monozygotic twins and it was maintained when corrected for body size by dividing response by body surface area. The variability within twin pairs was smaller for monozygotic twins than dizygotic twins. From these results, it was suggested that genetic factors are responsible for the variation of hypercapnic ventilatory response in normal young people.
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Miyamura et al. (1982) studied this question.
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