Why the study?
The accuracy of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens remains unknown in hypertrophic cardiomyopathy.
Does cardiac magnetic resonance imaging with late gadolinium enhancement predict microscopic myocardial scarring in patients with hypertrophic cardiomyopathy?
Comparison
Late gadolinium enhancement vs endomyocardial biopsy
Design
Retrospective study
Key result
Late gadolinium enhancement in the whole heart demonstrated 100% sensitivity for predicting microscopic myocardial scarring and independently correlated with the collagen fraction (β=0.59) in HCM.
Authors
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May support broader LGE-CMR use in HCM; challenges weak consensus against benefit and extends histological correlation.
Observational (n=21)
Blinded analysis
No
Does cardiac magnetic resonance imaging with late gadolinium enhancement predict microscopic myocardial scarring in patients with hypertrophic cardiomyopathy?
Effect estimate: β 0.59 (95% CI 0.15-1.0)
p-value: p=0.012
LGE-CMR has excellent sensitivity for detecting microscopic myocardial scarring in HCM, and its extent correlates with the quantitative collagen fraction, suggesting it can noninvasively predict myocardial scarring.
今野 et al. (2014) conducted an observational in Hypertrophic cardiomyopathy (n=21). Late gadolinium enhancement cardiac magnetic resonance imaging vs. Endomyocardial biopsy was evaluated on Microscopic collagen fraction in biopsied specimens (β 0.59, 95% CI 0.15-1.0, p=0.012). Late gadolinium enhancement in the whole heart demonstrated 100% sensitivity for predicting microscopic myocardial scarring and independently correlated with the collagen fraction (β=0.59) in HCM.