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The aim is to analyze and isolate sphingolipid bases from rat brain, liver, and kidney tissues.

April 1, 2026Open Access

Studies on Sphingolipids, II. Sphingolipid Bases in Rat Brain, Liver and Kindney.

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Analyzes sphingolipid bases in rat brain, liver, and kidney, indicating variations in composition across tissues.

The aim is to analyze and isolate sphingolipid bases from rat brain, liver, and kidney tissues.
Isolated sphingolipids from rat brain, liver, and kidney using methods of Gayer and Sweely.
Analyzed sphingosine bases using gas-liquid chromatography after periodate oxidation of aldehydes.
Determined sphingosine base composition and quantities through various chromatographic techniques.
Sphingosine bases mostly comprised C18-sphingosine (70-93%) and C18-dihydrosphingosine (4-15%) across all tissues.
Brain mucolipid contained 23% C20-sphingosine; sphingomyelin had 3%, with no C20-sphingosine in cerebroside or sulfatide.
C18-dihydrosphingosine occurred more frequently in cerebroside than in sphingomyelin.
Liver cerebroside contained 7.5% phytosphingosine along with other sphingosine bases; lesser amounts found in kidney cerebroside.

Akino Toyoaki (1969) studied this question.

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