Gout in the era of multimorbidity: pathogenesis, systemic comorbidities, and evolving therapeutic strategies

March 31, 2026Kosin Medical JournalOpen Access

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Key Points

Examine the pathogenesis of gout and its systemic comorbidities, focusing on evolving treatment strategies.
Literature review of gout pathogenesis and associated comorbid conditions.
Analysis of hyperuricemia causes and its role in gout development.
Overview of current therapeutic strategies including imaging and pharmacologic therapies.
Gout is primarily caused by hyperuricemia from disordered purine metabolism.
The disease is linked with metabolic syndrome, chronic kidney disease, and cardiovascular disease, increasing mortality risk.
Real-world usage of urate-lowering therapy is noted to be suboptimal despite advancements in treatment.

Review highlights gout pathogenesis and comorbidities, emphasizing improved therapy implications for health outcomes.

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Kim et al. (2026) studied this question.

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