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April 1, 2026Chemical Science3 citationsOpen Access

From alkynes to spiroindole δ-lactams via a copper-nitrenoid intermediate featuring unusual 1,1-addition and high Z -selectivity

ZRZhiqiang RenTFTianhui FengYLYeyao Li

Key Points

  • This research aims to develop a synthesis method for spiroindole δ-lactams using copper catalysts.
  • Utilized NHC-copper catalysis for the reaction
  • Combined dioxazolones with alkyne derivatives
  • Emphasized 1,1-addition and Z-selectivity
  • Achieved excellent yields and high atom economy
  • Demonstrated broad functional group tolerance
  • Showed significant Z-selectivity in the final products

Abstract

NHC-copper-catalyzed strategy has been developed for the synthesis of spiroindole δ-lactams from dioxazolones and alkyne derivatives. The methodology offers high atom economy, excellent yields, broad functional group tolerance, and Z -selectivity.

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Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/69cd7b345652765b073a904chttps://doi.org/10.1039/d5sc09742h
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