This preliminary study shows differences in COX-1 and COX-2 expression in head and neck squamous cell carcinoma, suggesting potential treatment targets.
To clarify difference in terms of the expression of cyclooxygenase-1 (COX-1) and cyclooxyge- nase-2 (COX-2) in squamous cell carcinoma in the head and neck (HNSCC), an immunohistochemi- cal study was performed for specimens obtained from 4 patients with HNSCC, and 3 normal volun- teers. COX-1 and COX-2 expressions were observed in small round cells, plasma cells and fibrob- lasts in interstitial tissue. An apparent difference in expression between COX-1 and COX-2 is that strong positive COX-2 expression was recognized in mitosis in 2 HNSCC patients, whereas COX-1 immunoreactivity was not seen in mitosis among 4. These preliminary findings suggest that COX-2 may have an important role in proliferation of HNSCC and COX-2 can be a target for the prevention or treatment of HNSCC.
No takes yet. Share an insight, caveat, or question.
Haginomori et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: