Curcumin-AuNP-loaded electroconductive hydrogels significantly attenuated cardiac damage, reduced infarct size, and preserved heart function in rats with isoproterenol-induced myocardial injury.
Does curcumin-AuNP loaded electroconductive hydrogel reduce infarct size and improve cardiac function in rats with isoproterenol-induced myocardial injury?
Curcumin-mediated AuNP-loaded electroconductive hydrogels demonstrate strong preclinical potential for reducing infarct size and preserving cardiac function post-myocardial infarction.
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ABSTRACT Myocardial infarction (MI), a leading global cause of death, triggers substantial cardiomyocyte loss and heart dysfunction. Current treatments, including guideline‐directed cardioprotective drugs and revascularization, face limitations such as poor durability, donor shortages, and immune rejection. Injectable hydrogels and cardiac patches offer promising avenues for post‐MI tissue regeneration, with electrical conductivity enhancing cardiac function. Curcumin‐gold nanoparticles (AuNPs) further mitigate inflammation, oxidative stress, and infarct size. This study integrates curcumin‐AuNPs with an electroconductive nanocomposite hydrogel via green chemistry, using curcumin as both a reducing and stabilizing agent. The resulting AuNPs exhibited a diameter of 32 ± 9 nm and zeta potential of −29.6 mV. Incorporation into the hydrogel yielded a porous nanocomposite (70%–80% porosity with interconnected pores, confirmed by SEM) that was biocompatible and multifunctional. In vitro antioxidant assays showed dose‐dependent radical scavenging by AuNPs, peaking at 50 μg/mL. In isoproterenol‐induced myocardial injury rats, hydrogel/AuNP administration significantly attenuated cardiac damage, reducing inflammation, oxidative stress, and infarct size while preserving function. These findings demonstrate that curcumin‐mediated AuNPs enable multifunctional, porous, antioxidant, and cardioprotective hydrogels with strong preclinical potential for MI repair and cardiovascular therapies.
Zhao et al. (Mon,) reported a other. Curcumin-AuNP-loaded electroconductive hydrogels significantly attenuated cardiac damage, reduced infarct size, and preserved heart function in rats with isoproterenol-induced myocardial injury.