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April 1, 2026Indian Journal of Pathology and MicrobiologyOpen Access

Prognostic value of tumor-infiltrating lymphocytes in colon cancer

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Authors

BDBacha DhouhaTunis UniversityKNKhessairi NeyssemInstitut Salah-AzaïzKNKammoun NeirouzHôpital Mongi Slim

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Implication

Retrospective study assesses tumor-infiltrating lymphocytes as a marker of recurrence risk in stage II colon cancer, suggesting clinical application.

Key Points

  • The aim is to evaluate the prognostic significance of tumor-infiltrating lymphocytes in patients with stage II colon cancer.
  • Conducted a retrospective study of patients who underwent surgery for stage II colonic adenocarcinoma.
  • Data collected over a 15-year period involving 70 patients.
  • Analyzed recurrence-free survival and overall survival rates in correlation with tumor-infiltrating lymphocytes.
  • TIL rates varied from 3% to 80%, with a median of 50%.
  • TIL rates below 50% correlated with significantly decreased recurrence-free survival (P = 0.001).
  • Identified as an independent factor for recurrence-free survival in multivariate analysis.
  • A correlation was found between TILs < 50% and lymphatic invasion, high tumor grade, and tumor size > 3 cm.

Cite This Study

Dhouha et al. (2026) studied this question.

synapsesocial.com/papers/69cd7b575652765b073a9431https://doi.org/10.4103/ijpm.ijpm_710_24
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