Transgenic approaches enhance mycotoxin detoxification in cereal crops, suggesting a method for food safety improvement.
Trichothecene 3-O-acetyltransferase (encoded by Tri101) inactivates the virulence factor of the cereal pathogen Fusarium graminearum. Zearalenone hydrolase (encoded by zhd101) detoxifies the oestrogenic mycotoxin produced by the same pathogen. These genes were introduced into a model monocotyledon rice plant to evaluate their usefulness for decontamination of mycotoxins. The strong and constitutive rice Actl promoter did not cause accumulation of TRI101 protein in transgenic rice plants. In contrast, the same promoter was suitable for transgenic production of ZHD101 protein ; so far, five promising To plants have been generated. Low transgenic expression of Tri101 was suggested to be increased by addition of an Ω enhancer sequence upstream of the start codon.
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Higa et al. (2003) studied this question.
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