Why the study?
Does IVUS guidance during DES implantation improve long-term health outcomes and mortality in patients undergoing invasive coronary treatment?
Does IVUS guidance during DES implantation improve long-term health outcomes and mortality in patients undergoing invasive coronary treatment?
IVUS guidance during DES implantation did not show superiority over standard high-pressure postdilatation for long-term outcomes, though significant risks of stent thrombosis after DAPT discontinuation were noted.
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IVUS guidance adds no long-term benefit over high-pressure postdilatation in DES; challenges routine IVUS adoption and warrants further outcome trials.
In our randomized trial we failed to demonstrate the superiority of the IVUS guidance during DES implantation over standard high-pressure postdilatation. However we confirmed worrisome results concerning DES thrombosis after discontinuation of dual antiplatelet-treatment with documented stent thrombosis related events in almost 5% of patients with 50% of mortality in this high-risk clinical scenario.
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Jakabčin et al. (2009) studied this question.
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