Why the study?
Does more intensive blood pressure lowering reduce mortality in patients with hypertension and chronic kidney disease stages 3 to 5?
Population
Trial participants with hypertension and chronic kidney disease (CKD) stages 3 to 5
Comparison
More intensive blood pressure lowering vs Less intensive blood pressure lowering
Design
Randomized to more intensive vs less intensive BP control
Authors
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Supports intensive BP control to reduce mortality in hypertensive CKD; challenges prior low-certainty evidence against benefit.
Does more intensive blood pressure lowering reduce mortality in patients with hypertension and chronic kidney disease stages 3 to 5?
More intensive blood pressure control is associated with reduced mortality in patients with hypertension and advanced chronic kidney disease.
Malhotra et al. (2017) studied this question.
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