Reports how fungal immunomodulatory proteins shift macrophage behavior to inhibit tumor growth, suggesting new cancer therapies.
rFIP-nha inhibited tumour growth in two distinct ways, by targeting tumour cells directly and by directing macrophage polarization towards a tumour inhibitory phenotype. This dual bioactivity makes FIP-nha interesting as an additive support in cancer immunotherapy.
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Liu et al. (2026) studied this question.
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