Subgenual anterior cingulate cortex in major depression: a systematic review and meta-analysis of MRI studies with patients and healthy controls

March 31, 2026Translational PsychiatryOpen Access

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Key Points

To investigate the differences in the subgenual anterior cingulate cortex in individuals with major depression using MRI.
Conducted a systematic review and meta-analysis of existing MRI studies.
Compared structural and functional characteristics of the sgACC in major depression patients and healthy controls.
Assessed voxel-wise differences in GM volume, activity levels, and network coherence.
Identified non-uniform patterns in GM volume across different subregions of the sgACC.
Found significant variations in activity and network coherence in patients with major depression.
Highlighted the importance of high-resolution parcellation for future MRI investigations.

This systematic review analyzes MRI data to uncover GM volume differences in major depression, suggesting implications for future studies.

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Demchenko et al. (2026) studied this question.

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