What question did this study set out to answer?

To identify subgenual anterior cingulate cortex functional connectivity abnormalities in major depressive disorder and develop an individualized transcranial magnetic stimulation targeting algorithm using brain imaging big data.

March 11, 2023Open Access

Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation

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To identify subgenual anterior cingulate cortex functional connectivity abnormalities in major depressive disorder and develop an individualized transcranial magnetic stimulation targeting algorithm using brain imaging big data.
Analyzed resting-state functional MRI data from a multi-site cross-sectional cohort of 1,660 patients with major depressive disorder and 1,341 healthy controls from Phase II of the DIRECT consortium.
Mapped case-control differences in subgenual anterior cingulate cortex (sgACC) functional connectivity and evaluated their impact on target localization in the left dorsolateral prefrontal cortex (DLPFC).
Developed and tested an individualized TMS targeting algorithm combining group-level statistical maps with individual-level brain scans across two independent clinical samples.
Patients with depression exhibited significantly enhanced functional connectivity between the sgACC and left DLPFC compared to healthy controls.
Case-control connectivity differences altered the location of the sgACC anti-correlation peak in the left DLPFC, with the magnitude of these differences directly correlating with clinical symptom improvement in two independent cohorts.
The big data-guided targeting algorithm produced personalized TMS stimulation sites that were clinically superior to standard group-level coordinates.

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Implication

Cross-sectional neuroimaging study reveals abnormal subgenual cingulate connectivity in depression, suggesting big data can personalize transcranial magnetic stimulation targets.

Cite This Study

Chen et al. (2023) studied this question.

synapsesocial.com/papers/6aa145ab1a7bbc7949777594 https://doi.org/10.1101/2023.03.09.531726

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Implication

Cross-sectional neuroimaging study reveals abnormal subgenual cingulate connectivity in depression, suggesting big data can personalize transcranial magnetic stimulation targets.

Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation

Key Points

Discussion

Implication

Cite This Study

Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation

Key Points

Discussion

Implication

Cite This Study