Key result
Higher creatinine-to-cystatin C/waist circumference ratio linked to ~36% lower dyslipidemia risk.
Why the study?
The predictive value of the creatinine-to-cystatin C/waist circumference ratio (CCR/WC) for dyslipidemia and its mediating role in hypertension pathogenesis were undefined.
Does a higher CCR/WC ratio predict a lower risk of dyslipidemia and mediate hypertension risk in middle-aged and older adults?
Cohort (n=7,117)
Yes
Does a higher CCR/WC ratio predict a lower risk of dyslipidemia and mediate hypertension risk in middle-aged and older adults?
The CCR/WC ratio serves as a useful composite biomarker for predicting dyslipidemia and stratifying hypertension risk in middle-aged and older adults.
May enhance dyslipidemia and hypertension risk stratification in middle-aged adults; extends composite biomarker evidence but should not yet change practice.
The creatinine-to-cystatin C/waist circumference ratio (CCR/WC) combines renal function and adiposity metrics, yet its predictive value for dyslipidemia remains undefined. This research examined CCR/WC’s capacity as a dyslipidemia biomarker and its mediating role in hypertension pathogenesis. Utilizing the China Health and Retirement Longitudinal Study (CHARLS) cohort, we employed multivariable-adjusted logistic regression and Cox proportional hazards models to quantify CCR/WC-dyslipidemia associations. Nonlinear patterns were assessed using restricted cubic splines, and mediation analysis was conducted to evaluate the role of dyslipidemia in the relationship between CCR/WC and hypertension. Among 7,117 participants, elevated CCR/WC demonstrated a 36% reduced dyslipidemia risk (fully adjusted OR = 0.64; 95%CI: 0.43–0.95). No nonlinear relationship between CCR/WC and dyslipidemia was observed. Cox proportional hazards analysis revealed progressive risk reduction with higher CCR/WC quartiles (vs. Q1): Q2(HR = 0.82), Q3(HR = 0.72), Q4(HR = 0.76). Dyslipidemia mediated CCR/WC’s effect on hypertension (indirect effect=-0.017; 95%CI: -0.033 to -0.006). The CCR/WC ratio serves as a composite biomarker for dyslipidemia and hypertension risk stratification, highlighting its potential clinical utility.
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Yang et al. (2026) conducted a cohort in Dyslipidemia (n=7,117). Elevated CCR/WC ratio vs. Lower CCR/WC ratio was evaluated on Dyslipidemia risk (OR 0.64, 95% CI 0.43-0.95, p=0.030). An elevated creatinine-to-cystatin C/waist circumference ratio was associated with a 36% reduced risk of dyslipidemia in middle-aged and older adults.
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