Acromegaly is Associated with an Increased Incidence of Primary Malignant Tumors: Data from a National Study in Sweden

Erika Tsatsaris; Jonas Robert; Pia Burman; Katarina Berinder; Lorenza Bonelli; Per Dahlqvist; Charlotte Höybye; Óskar Ragnarsson; Konstantina Vouzouneraki; Anna-Karin Åkerman; Bertil Ekman; Britt Edén Engström

doi:10.1210/clinem/dgag137

March 27, 2026The Journal of Clinical Endocrinology & MetabolismOpen Access

Acromegaly is Associated with an Increased Incidence of Primary Malignant Tumors: Data from a National Study in Sweden

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Key Points

This research aims to evaluate the cancer risk associated with acromegaly and its relation to growth hormone levels.
Nationwide matched cohort study design
Comparison of cancer incidence in patients with acromegaly versus matched controls
Assessment of biochemical control effects on cancer development
Increased cancer incidence observed in patients with acromegaly
Biochemical control had minimal impact on reducing cancer risk
Findings suggest risks extend beyond just growth hormone hypersecretion

Implication

Matched cohort study shows increased cancer risk in acromegaly, indicating need for monitoring.

Abstract

This nationwide, matched cohort study showed an increased risk of cancer in patients with acromegaly, underscoring the importance of vigilance for early signs of cancer after acromegaly diagnosis. Biochemical control had minor effects on increased cancer development, indicating an effect beyond GH hypersecretion.

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Cite This Study

Tsatsaris et al. (2026) studied this question.

synapsesocial.com/papers/69cf5c925a333a821460a286 https://doi.org/10.1210/clinem/dgag137

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Acromegaly is Associated with an Increased Incidence of Primary Malignant Tumors: Data from a National Study in Sweden

Key Points

Implication

Abstract

Discussion

Cite This Study

Acromegaly is Associated with an Increased Incidence of Primary Malignant Tumors: Data from a National Study in Sweden

Key Points

Implication

Abstract

Discussion

Cite This Study

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