Synthesis of Reagent FCH ₂ CF ₂ SO ₂ Na: A Source of the FCH ₂ CF ₂ • Radical and Useful for Introduction of the −SCF ₂ CH ₂ F Functionality into Organic Compounds

Methods for the direct 1,1,2-trifluoroethylation of molecules via oxidative or visible light photoredox radical generating processes are rare, as is chemistry for electrophilic 1,1,2-trifluoroethylthiolaton. Here, we report the preparation of a benchtop stable reagent, sodium 1,1,2-trifluoroethanesulphinate, that functions to introduce such groups into a broad variety of electron deficient and electron rich heteroaromatic and unactivated alkene systems, using oxidative processes to generate the 1,1,2-trifluoroethyl radical and the reagent PCl₃ to introduce the 1,1,2-trifluoroethylthio group.