Correction: Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis

Key Points

The aim is to clarify the role of coronavirus endoribonuclease nsp15 in host protein synthesis suppression.
Corrects previously published findings
Analyzes interactions between nsp15 and host translation machinery
Examines PKR-eIF2α pathway effects on viral protein synthesis
Nsp15 effectively suppresses host protein synthesis
Demonstrates evasion of PKR-eIF2α-mediated translation shutoff
Ensures viral protein synthesis continuity despite host defenses

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Correction highlights how coronavirus endoribonuclease counters host translation mechanisms, suggesting implications for viral replication.

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Gong et al. (2026) studied this question.

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