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April 3, 2026ACS Chemical Neuroscience

Propionate Aggravates Anxiety and Cognitive Dysfunction in High-Fat Diet Mice by Activating Hippocampal Microglia-Mediated Neuroinflammation

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Authors

XZXu ZuoHBHuijuan BaiQZQili Zhao

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Overview

Experimental study reveals propionate worsens anxiety and cognitive dysfunction in high-fat diet mice, suggesting possible health risks.

Key Points

  • The research examines how propionate affects anxiety, cognitive function, and related metabolic disturbances in high-fat diet mice.
  • Used six-week-old male Balb/c mice divided into four treatment groups (standard diet, propionate, high-fat diet, high-fat diet with propionate).
  • Administered propionate at a dosage of 15 mg/kg for six weeks.
  • Assessed behavioral changes using anxiety and cognitive tests such as the elevated plus maze and novel object recognition test.
  • Examined neural changes including microglial activation and cytokine levels in the hippocampus.
  • HFD+Pro group showed greater weight gain and increased insulin resistance compared to the HFD group.
  • Mice exhibited more pronounced anxiety-like and cognitive impairments.
  • HFD+Pro treatment led to hippocampal neuronal loss and increased pro-inflammatory cytokines (Il-6, Il-1β).
  • There was a downregulation of anti-inflammatory cytokines (Il-4, Il-10) in the HFD+Pro group.

Cite This Study

Zuo et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ced5a333a821460a832https://doi.org/10.1021/acschemneuro.6c00015
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