Key result
Post-TAVR PPM linked to lower ischemic stroke risk without increasing mortality or MACE.
Why the study?
Does permanent pacemaker implantation after TAVR affect mortality, MACE, or ischemic stroke risk in patients undergoing TAVR?
Does permanent pacemaker implantation after TAVR affect mortality, MACE, or ischemic stroke risk in patients undergoing TAVR?
Permanent pacemaker implantation after TAVR may confer cerebrovascular protection by lowering ischemic stroke risk without increasing mortality or MACE.
May confer stroke protection post-TAVR without raising mortality or MACE; leaves open causality pending randomized confirmation.
PPM after TAVR was not associated with increased mortality or MACE but was independently associated with significantly lower ischemic stroke risk. Late PPM implantation showed a trend toward worse outcomes. These findings suggest that appropriately indicated PPM may confer cerebrovascular protection, and early implantation when indicated may be preferable. These findings warrant further validation in prospective studies.
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Saleh et al. (2026) studied this question. Permanent pacemaker implantation after TAVR was independently associated with significantly lower ischemic stroke risk without increasing mortality or major adverse cardiovascular events.
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