Immutable and Variable Mechanisms in Synaptic Modulation of Various Types of Skeletal Muscles

An overview of data on studies of multi-vector, as well as the persistence of unidirectional synaptic modulation in various types of motor units, is presented. As is known, modulators of synaptic transmission are numerous. These include the main mediators directly involved in this synapse, neuropeptides (endorphins and enkephalins, calcitonin, substance P, etc.), fatty acid derivatives (arachidonic acid and eicosanoids), gaseous mediators (NO, CO, and H2S), as well as purines and pyrimidines (extracellular ATP, adenosine, etc.). Using the example of data analysis based on the results of the action of the most effective neuromodulators, purines, both their constant and variable effects in the synaptic modulation of various types of skeletal muscles were revealed.