Key result
μFR-guided grafting is linked to lower arterial graft failure, but shows no clinical benefit.
Why the study?
Does μFR guidance reduce graft failure and improve clinical outcomes in patients undergoing multi-arterial CABG?
Cohort
Does μFR guidance reduce graft failure and improve clinical outcomes in patients undergoing multi-arterial CABG?
Murray's Law-Based Quantitative Flow Ratio (μFR) guidance is associated with lower arterial graft failure rates in multi-arterial CABG, though it does not appear to improve mid-term clinical outcomes.
In patients undergoing multi-arterial CABG, grafting strategies meeting μFR guidance were associated with a significantly lower failure rate of arterial grafts but not venous grafts. However, no improvement in mid-term clinical outcomes was observed, and larger trials are warranted in the future (Quantitative Flow Ratio on Radial Artery Graft Outcome After Coronary Artery Bypass Grafting [ASRAB-QUARGO]; NCT05556590).
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Qi et al. (2026) conducted a cohort in Multi-arterial coronary artery bypass grafting (CABG). Grafting strategies meeting Murray's Law-based quantitative flow ratio (μFR) guidance vs. Grafting strategies not meeting μFR guidance was evaluated on Failure rate of arterial and venous grafts, and mid-term clinical outcomes. Grafting strategies meeting μFR guidance were associated with a significantly lower failure rate of arterial grafts, but not venous grafts, with no improvement in mid-term clinical outcomes.
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