Analysis of 15 years of hepatitis C virus dynamics shows significant improvements due to direct-acting antivirals, despite disruptions from global crises.
Key Points
This analysis aims to evaluate the temporal trends of hepatitis C virus infection and the impact of direct-acting antivirals over 15 years in Türkiye.
Analyzed laboratory data from patients tested for anti-HCV antibodies and HCV-RNA between 2011 and 2025.
Categorized positive patients by antibody titers and viremia status.
Applied Poisson, beta, and quantile regression models to assess trends in case numbers and positivity rates.
Over 402,557 patients were screened for anti-HCV over 15 years.
The number of high-titer positive patients decreased four-fold, while annual test volume increased by 2.25 times.
HCV-RNA positivity rates declined approximately 19.2% annually after 2017.
The median age of viremic patients increased by over 5.5 years throughout the study period.
Cite This Study
YAKUPOĞULLARI et al. (2026) studied this question.