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December 7, 2022JAMA Network OpenOpen Access

Characteristics and Treatment Rate of Patients With Hepatitis C Virus Infection in the Direct-Acting Antiviral Era and During the COVID-19 Pandemic in the United States

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Why the study?

Clinical data on hepatitis C virus (HCV) treatment rates in the United States are sparse.

What are the treatment rates and factors associated with direct-acting antiviral therapy among privately insured patients with Hepatitis C in the US?

Population

133 348 privately insured patients with HCV in the US

Design

Retrospective cohort study

Authors

VNVy H. NguyenLKLeslie Y. KamYYYee Hui Yeo

Discussion

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Overview

Suboptimal 65% DAA treatment rates with post-2019 declines signal persistent care gaps; leaves open need for strategies to boost uptake in insured populations.

Structured PICO

What are the treatment rates and factors associated with direct-acting antiviral therapy among privately insured patients with Hepatitis C in the US?

P
Population
133,348 privately insured patients with Hepatitis C Virus (HCV) in the United States, mean age 59.7 years, 59.7% male. Includes a subgroup of 20,277 patients with positive HCV RNA.
I
Intervention
Direct-acting antivirals (DAAs)
O
Outcome
HCV treatment rate and changes over time

Despite the high efficacy of direct-acting antivirals, less than two-thirds of insured US patients with viremic HCV receive treatment, with rates declining significantly during the COVID-19 pandemic.

Cite This Study

Nguyen et al. (2022) studied this question.

synapsesocial.com/papers/6a893824b4e829b19bd43858https://doi.org/10.1001/jamanetworkopen.2022.45424
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct-Acting Antivirals Are a Milestone for Hepatitis C Virus Infection? Analysis of 15 Years of Patient and Diagnosis Data from a Region in Türkiye2026
  2. 2<scp>HCV</scp> Testing and Treatment of Adults in the United States: 2014 Through 2021—Data From Two National Commercial Testing Laboratories2025
  3. 3Trends in hepatocellular carcinoma (HCC) incidence and impact of hepatitis C antiviral therapy: A population-based subgroup analysis.2026
  4. 4Early PCR Confirmation and Fewer Visit as the Key to Improving HCV Treatment Rates in a Predominantly African American GI Clinic2024
  5. 5Hepatitis C epidemiology and treatment outcomes in Italy: Impact of the <scp>DAA</scp> era and the <scp>COVID</scp>‐19 pandemic2024 · 5 citations