What question did this study set out to answer?

The research aims to explore the role of RAD51 gene variants in the susceptibility to non-syndromic orofacial clefts.

April 3, 2026Orthodontics and Craniofacial Research0 citations

Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non‐Syndromic Orofacial Clefts in a Han Chinese Population

SGS F GuoBeijing Obstetrics and Gynecology Hospital TGTingting GuoBeijing Obstetrics and Gynecology Hospital YXYi Lin XuNanjing Agricultural University

Puntos clave

The research aims to explore the role of RAD51 gene variants in the susceptibility to non-syndromic orofacial clefts.
Identified RAD51 variants rs45507396 and rs1801320
Analyzed genetic data from Han Chinese individuals
Compared variant frequencies between orofacial cleft cases and controls
Variants rs45507396 and rs1801320 are significantly associated with non-syndromic orofacial clefts
Findings provide new genetic insight into cleft susceptibility
Establishes a theoretical basis for further molecular research

Resumen

This study is the first to identify RAD51 variants rs45507396 and rs1801320 as susceptibility loci for NSOFC in the Han Chinese population, providing novel genetic insights and a theoretical basis for further investigation into the molecular mechanisms of NSOFC.

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