Animal study demonstrates nephroprotection from TiO2 nanoparticle toxicity using Thymus numidicus essential oil, suggesting its therapeutic potential.
We studied the protective impacts of Thymus numidicus Poiret essential oil (TEO) on the nephrotoxicity induced by TiO2 nanoparticles (NPs) at both histological and oxidative levels. Adult male albino rats were randomly divided into four groups: Group-I: Control, Group-II: Received 12 mg/kg/day of TiO2 NPs, Group-III: Received 4μL/kg/day of Thymus numidicus Poiret essential oil and Group-IV: Administered Essential oil and TiO2 NPs for 30 days. Administered TiO2 NPs significantly increased the serum uric acid levels and creatinine levels than control. Furthermore, rats exposed to TiO2 NPs increased MDA content with reduction in renal GSH, GPx and GST activities when compared with control. Renal toxicities induced by TiO2 NPs were evident through disturbances in oxidative-antioxidant system and changes in serum renal markers. However, these changes were prevented and the antioxidant status was preserved when experimental rats were treated with Thymus numidicus Poiret essential oil. The biochemical evidence of nephroprotection was supported by the histological findings. This study demonstrated that Thymus numidicus Poiret essential oil significantly decreased the adverse effects of TiO2 NPs, highlighting its role in reducing nanoparticle-induced renal dysfunction. Its nephroprotective activity was attributed to its chemical composition and antioxidant properties.
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Maroua et al. (2026) studied this question.
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