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April 3, 2026The Journal of BiochemistryOpen Access

Regulatory dynamics of monosomes and polysomes in cellular adaptation

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Authors

HIHirotatsu ImaiUniversity of the RyukyusAYAkio YamashitaKindai University

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Implication

This review summarizes how monosomes and polysomes regulate protein synthesis in mammals, highlighting their roles during environmental stress.

Key Points

  • This review explores how monosomes and polysomes function in mRNA translation and cellular adaptation under stress.
  • Review of existing literature on monosome and polysome dynamics
  • Analysis of translational profiles in mammalian cells
  • Examination of the monosome-to-polysome ratio during stress conditions
  • Monosomes and polysomes show distinct translational profiles influencing protein synthesis.
  • Environmental stresses alter the monosome-to-polysome ratio, indicating their adaptive roles.
  • Non-translating monosomes form under varying biological conditions, contributing to gene regulation.

Cite This Study

Imai et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d605a333a821460b0e7https://doi.org/10.1093/jb/mvag026
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