Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 3, 2026Irish Journal of Medical Science (1971 -)Open Access

Network-based discovery of gene-miRNA interactions associated with hepatocellular carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

MIMurat ISIYELAtatürk UniversityHCHamid CeylanAtatürk University

Discussion

Loading...

Member takes

Implication

Analysis identifies key gene-miRNA interactions associated with liver cancer progression and survival implications.

Key Points

  • This research aims to discover regulatory interactions between genes and miRNAs that contribute to hepatocellular carcinoma (HCC).
  • Analyzed transcriptomic data from twelve GEO microarray datasets.
  • Identified differentially expressed genes (DEGs) and miRNAs (DEmİRs) in tumor vs. non-tumorous liver tissue.
  • Created a protein-protein interaction (PPI) network to determine hub genes.
  • Conducted gene ontology and pathway enrichment analysis.
  • Performed in silico analyses to assess gene expression and prognostic impact.
  • Identified three hub genes (AURKA, CCNB1, KIF11) significantly linked to cancer progression.
  • Found downregulated miRNAs (hsa-miR-335-3p, hsa-miR-2355-5p, hsa-miR-3163) that target hub genes.
  • Hub genes associated with reduced overall survival and protein kinase binding activity.

Cite This Study

ISIYEL et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d605a333a821460b14ehttps://doi.org/10.1007/s11845-026-04303-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis2024 · 6 citations
  2. 2USO1 isoforms differentially promote liver cancer progression by dysregulating the ER–Golgi network2021 · 9 citations
  3. 3Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population‐based lymph node negative breast cancer cohort2009 · 64 citations
  4. 4Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis2013 · 126 citations