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The review examines advancements in treatment for locally advanced esophageal cancer, focusing on multimodality strategies.

April 3, 2026Open Access

Esophageal Cancer – Finally a Light at the End of the Tunnel?

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The review examines advancements in treatment for locally advanced esophageal cancer, focusing on multimodality strategies.
Review of existing literature on surgical treatment and chemoradiotherapy outcomes.
Analysis of the Cross Trial findings regarding neoadjuvant therapy.
Evaluation of the CHECKMATE-577 study on adjuvant immunotherapy effects.
Neoadjuvant chemoradiotherapy shows clear superiority over surgery alone.
New questions arise regarding the necessity of radiotherapy for all histological types.
Adjuvant immunotherapy is beneficial and suggests new directions for treatment.

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This review explores treatment evolution and suggests future pathways for locally advanced esophageal cancer, implying new implications for therapy.

Sabyasachi Bal (2025) studied this question.

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This review explores treatment evolution and suggests future pathways for locally advanced esophageal cancer, implying new implications for therapy.